PT  - JOURNAL ARTICLE
AU  - Emmanouela Sdona
AU  - Jenny Hallberg
AU  - Niklas Andersson
AU  - Sandra Ekström
AU  - Susanne Rautiainen
AU  - Niclas Håkansson
AU  - Alicja Wolk
AU  - Inger Kull
AU  - Erik Melén
AU  - Anna Bergström
TI  - Dietary antioxidant intake in school age and lung function development up to adolescence
AID  - 10.1183/13993003.00990-2019
DP  - 2019 Jan 01
TA  - European Respiratory Journal
PG  - 1900990
4099  - http://erj.ersjournals.com/content/early/2019/11/13/13993003.00990-2019.short
4100  - http://erj.ersjournals.com/content/early/2019/11/13/13993003.00990-2019.full
AB  - Dietary antioxidant intake has been hypothesised to influence lung function. The association between total antioxidant capacity (TAC) of the diet at age 8 years and lung function development up to 16 years in 2307 participants from the Swedish population-based birth cohort BAMSE was investigated.Information on TAC was obtained from a food frequency questionnaire at 8 years. Lung function was measured by spirometry at 8 and 16 years, impulse oscillometry (IOS) and fractional exhaled nitric oxide (FENO) at 16 years. Low lung function was defined as forced expiratory volume in 1 s (FEV1) z-score below the 25th percentile. Longitudinal associations between TAC and lung function were analysed by mixed effect models adjusted for potential confounders. Stratification by asthma at 8 years was performed to examine effect modification.The median TAC intake was 10 067 μmol TE/g, with boys having a lower mean compared to girls (9963 versus 10 819 μmol TE/g). In analyses of lung function change between 8 and 16 years, there were no statistically significant associations between TAC in tertiles and spirometry results for the total study population. Among children with asthma at 8 years (prevalence 7%), higher TAC was associated with higher mean FEV1 (0.46 sd, 95% CI:0.11;0.80) and decreased odds of low lung function at 16 years (OR 0.28, 95% CI:0.12;0.65). There were no associations between TAC and forced vital capacity or IOS/FENO results.High dietary antioxidant intake in school age may be associated with improved lung function development from school age to adolescence among children with asthma.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Sdona has nothing to disclose.Conflict of interest: Dr. Hallberg reports personal fees from AstraZeneca, outside the submitted work.Conflict of interest: Dr. Andersson has nothing to disclose.Conflict of interest: Dr. Ekström has nothing to disclose.Conflict of interest: Dr. Rautiainen has nothing to disclose.Conflict of interest: Dr. Håkansson has nothing to disclose.Conflict of interest: Dr. Wolk has nothing to disclose.Conflict of interest: Dr. Kull has nothing to disclose.Conflict of interest: Dr. Melén has nothing to disclose.Conflict of interest: Dr. Bergström has nothing to disclose.