TY - JOUR T1 - Tuberculosis following renal transplantation in England, Wales and Northern Ireland: a national registry-based cohort study JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02245-2018 VL - 54 IS - 4 SP - 1802245 AU - Rishi K. Gupta AU - Gabriel Rosenberg AU - Jaran Eriksen AU - Marc Lipman AU - Charlotte Jackson AU - Anjana Roy AU - Dominik Zenner AU - Colette Smith AU - Mark Harber AU - Colin Campbell AU - Ibrahim Abubakar Y1 - 2019/10/01 UR - http://erj.ersjournals.com/content/54/4/1802245.abstract N2 - Increased tuberculosis (TB) disease risk has consistently been observed among solid organ transplant recipients [1, 2]. This may result from post-transplant immunosuppressive therapy, although underlying disease processes leading to transplant (including chronic kidney disease) are also associated with increased risk [3]. TB among transplant recipients is associated with increased risk of drug toxicity, drug–drug interactions, graft failure and mortality [4], and can lead to transmission to other vulnerable hospitalised patients. Consequently, global guidelines recommend systematic screening of patients undergoing solid organ transplant for latent tuberculosis infection (LTBI) [3].Among a nationwide cohort of renal transplant recipients (n=30 433), TB incidence was highest in the first year post-transplant. Asian ethnicity and CMV seropositivity were independent risk factors for post-transplant TB http://bit.ly/2YSVGt2We are extremely grateful to the NHS Blood and Transplant team and Public Health England TB unit for maintaining and providing the linked data used in this study, along with the transplant centres and TB services who contributed the original data. ER -