TY - JOUR T1 - Profiles of tuberculosis disease activation among contacts of patients with tuberculosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00353-2019 VL - 54 IS - 4 SP - 1900353 AU - Yayehirad A. Melsew AU - Allen C. Cheng AU - Emma S. McBryde AU - Justin T. Denholm AU - EeLaine Tay AU - Romain Ragonnet AU - James M. Trauer Y1 - 2019/10/01 UR - http://erj.ersjournals.com/content/54/4/1900353.abstract N2 - The risk of a person progressing to tuberculosis (TB) disease after infection with Mycobacterium tuberculosis remains poorly understood, with some contacts developing TB in the early period following exposure, while others take many years to progress or never do so [1, 2]. We described profiles and patterns of contacts' progression to TB disease following exposure by linking a large, prospectively collected contact investigation dataset from Victoria, Australia to data on subsequent cases of active TB disease, after obtaining ethical approval from the Monash University, Human Research Ethics Committee. Unlike many past studies, this approach offers the opportunity to disaggregate by various characteristics of both index patient and exposed contact.The risk of TB reactivation among infected children increases as they reach the age of adolescence. BCG vaccination history seems to increase the risk of TB disease reactivation among adults exposed to Mycobacterium tuberculosis. http://bit.ly/2YReXej ER -