PT - JOURNAL ARTICLE AU - Fei Zhou AU - Yimin Wang AU - Yingmei Liu AU - Xuedong Liu AU - Li Gu AU - Xiaoju Zhang AU - Zenghui Pu AU - Guoru Yang AU - Bo Liu AU - Qingrong Nie AU - Bing Xue AU - Jing Feng AU - Qiang Guo AU - Jianhua Liu AU - Hong Fan AU - Jin Chen AU - Yongxiang Zhang AU - Zhenyang Xu AU - Min Pang AU - Yu Chen AU - Xiuhong Nie AU - Zhigang Cai AU - Jinfu Xu AU - Kun Peng AU - Xiangxin Li AU - Pingchao Xiang AU - Zuoqing Zhang AU - Shujuan Jiang AU - Xin Su AU - Jie Zhang AU - Yanming Li AU - Xiuhong Jin AU - Rongmeng Jiang AU - Jianping Dong AU - Yuanlin Song AU - Hong Zhou AU - Chen Wang AU - Bin Cao ED - , TI - Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network AID - 10.1183/13993003.02406-2018 DP - 2019 Aug 01 TA - European Respiratory Journal PG - 1802406 VI - 54 IP - 2 4099 - http://erj.ersjournals.com/content/54/2/1802406.short 4100 - http://erj.ersjournals.com/content/54/2/1802406.full SO - Eur Respir J2019 Aug 01; 54 AB - Although broad knowledge of influenza viral pneumonia has been established, the significance of non-influenza respiratory viruses in community-acquired pneumonia (CAP) and their impact on clinical outcomes remains unclear, especially in the non-immunocompromised adult population.Hospitalised immunocompetent patients with CAP were prospectively recruited from 34 hospitals in mainland China. Respiratory viruses were detected by molecular methods. Comparisons were conducted between influenza and non-influenza viral infection groups.In total, 915 out of 2336 adult patients with viral infection were enrolled in the analysis, with influenza virus (28.4%) the most frequently detected virus, followed by respiratory syncytial virus (3.6%), adenovirus (3.3%), human coronavirus (3.0%), parainfluenza virus (2.2%), human rhinovirus (1.8%) and human metapneumovirus (1.5%). Non-influenza viral infections accounted for 27.4% of viral pneumonia. Consolidation was more frequently observed in patients with adenovirus infection. The occurrence of complications such as sepsis (40.1% versus 39.6%; p=0.890) and hypoxaemia (40.1% versus 37.2%; p=0.449) during hospitalisation in the influenza viral infection group did not differ from that of the non-influenza viral infection group. Compared with influenza virus infection, the multivariable adjusted odds ratios of CURB-65 (confusion, urea >7 mmol·L−1, respiratory rate ≥30 breaths·min−1, blood pressure <90 mmHg (systolic) or ≤60 mmHg (diastolic), age ≥65 years) ≥3, arterial oxygen tension/inspiratory oxygen fraction <200 mmHg, and occurrence of sepsis and hypoxaemia for non-influenza respiratory virus infection were 0.87 (95% CI 0.26–2.84), 0.72 (95% CI 0.26–1.98), 1.00 (95% CI 0.63–1.58) and 1.05 (95% CI 0.66–1.65), respectively. The hazard ratio of 90-day mortality was 0.51 (95% CI 0.13–1.91).The high incidence of complications in non-influenza viral pneumonia and similar impact of non-influenza respiratory viruses relative to influenza virus on disease severity and outcomes suggest more attention should be given to CAP caused by non-influenza respiratory viruses.The high incidence of complications in non-influenza viral pneumonia and similar impact of non-influenza viruses relative to influenza virus on disease severity and outcomes suggest more attention should be given to CAP caused by non-influenza viruses http://bit.ly/2vRTvFK