PT  - JOURNAL ARTICLE
AU  - Dany Doiron
AU  - Kees de Hoogh
AU  - Nicole Probst-Hensch
AU  - Isabel Fortier
AU  - Yutong Cai
AU  - Sara De Matteis
AU  - Anna L. Hansell
TI  - Air pollution, lung function and COPD: results from the population-based UK Biobank study
AID  - 10.1183/13993003.02140-2018
DP  - 2019 Jul 01
TA  - European Respiratory Journal
PG  - 1802140
VI  - 54
IP  - 1
4099  - http://erj.ersjournals.com/content/54/1/1802140.short
4100  - http://erj.ersjournals.com/content/54/1/1802140.full
SO  - Eur Respir J2019 Jul 01; 54
AB  - Ambient air pollution increases the risk of respiratory mortality, but evidence for impacts on lung function and chronic obstructive pulmonary disease (COPD) is less well established. The aim was to evaluate whether ambient air pollution is associated with lung function and COPD, and explore potential vulnerability factors.We used UK Biobank data on 303 887 individuals aged 40–69 years, with complete covariate data and valid lung function measures. Cross-sectional analyses examined associations of land use regression-based estimates of particulate matter (particles with a 50% cut-off aerodynamic diameter of 2.5 and 10 µm: PM2.5 and PM10, respectively; and coarse particles with diameter between 2.5 μm and 10 μm: PMcoarse) and nitrogen dioxide (NO2) concentrations with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), the FEV1/FVC ratio and COPD (FEV1/FVC <lower limit of normal). Effect modification was investigated for sex, age, obesity, smoking status, household income, asthma status and occupations previously linked to COPD.Higher exposures to each pollutant were significantly associated with lower lung function. A 5 µg·m−3 increase in PM2.5 concentration was associated with lower FEV1 (−83.13 mL, 95% CI −92.50– −73.75 mL) and FVC (−62.62 mL, 95% CI −73.91– −51.32 mL). COPD prevalence was associated with higher concentrations of PM2.5 (OR 1.52, 95% CI 1.42–1.62, per 5 µg·m−3), PM10 (OR 1.08, 95% CI 1.00–1.16, per 5 µg·m−3) and NO2 (OR 1.12, 95% CI 1.10–1.14, per 10 µg·m−3), but not with PMcoarse. Stronger lung function associations were seen for males, individuals from lower income households, and “at-risk” occupations, and higher COPD associations were seen for obese, lower income, and non-asthmatic participants.Ambient air pollution was associated with lower lung function and increased COPD prevalence in this large study.In one of the largest analyses to date, ambient air pollution exposure was associated with lower lung function and increased COPD prevalence, with stronger associations seen in those with lower incomes http://bit.ly/2DLBPA6