TY - JOUR T1 - Methylation, smoking, and reduced lung function JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00920-2019 VL - 54 IS - 1 SP - 1900920 AU - Stephanie J. London Y1 - 2019/07/01 UR - http://erj.ersjournals.com/content/54/1/1900920.abstract N2 - Imboden et al. [1] have produced a well-conducted epigenome-wide association study examining DNA methylation in blood across the genome in relation to lung function. The major finding is that various sites in the DNA from blood, previously identified in many studies to be strongly differentially methylated by smoking, are also reproducibly differentially methylated in relation to lung function in smokers.Epigenome-wide methylation studies have identified biomarkers of lifetime smoking; this study shows these are also related to lung function. While mechanisms are not clear, these studies could identify gene targets for prevention, screening and treatment. http://bit.ly/30F63i2 ER -