TY - JOUR T1 - Chronic cough: ATP, afferent pathways and hypersensitivity JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00889-2019 VL - 54 IS - 1 SP - 1900889 AU - Richard D. Turner AU - Surinder S. Birring Y1 - 2019/07/01 UR - http://erj.ersjournals.com/content/54/1/1900889.abstract N2 - Cough remains a vexing clinical problem in many contexts. Despite the identification of precipitating factors and relevant associated diagnoses, it is common for patients presenting to healthcare providers with persistent cough to remain unsatisfactorily treated [1]. Chronic cough is common and is associated with substantial physical and psychological morbidity [2].New evidence from tussive challenges and the P2X inhibitor gefapixant strengthens ATP as a driver of chronic cough. Cough responses to other irritants probably involve a separate peripheral activation pathway. Hypersensitivity may be due to distinct processes again. http://bit.ly/2YR6MuZThe authors are very grateful for comments on this manuscript by Stuart Mazzone, University of Melbourne. ER -