TY - JOUR T1 - Transbronchial Cryobiopsy for Diffuse Parenchymal Lung Disease: 30- and 90-Day Mortality JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00337-2019 SP - 1900337 AU - Jasleen Pannu AU - Lance J. Roller AU - Fabien Maldonado AU - Robert J. Lentz AU - Heidi Chen AU - Otis B. Rickman Y1 - 2019/01/01 UR - http://erj.ersjournals.com/content/early/2019/06/26/13993003.00337-2019.abstract N2 - Surgical lung biopsy (SLB) in diffuse parenchymal lung disease (DPLD) has been associated with significant in-hospital mortality (16% for non-elective patients, 1.7% for elective patients, overall 6.4%) [1, 2]. Overall 30-day mortality from SLB is reported at 1.5–4.5% from case series and 2.4% from a large European database [3]. Transbronchial cryobiopsy (TBC) has been proposed as a safer alternative to SLB for diagnosis of DPLD [4]. Existing studies on TBC report immediate procedural complications, but data on mortality at 30 and 90 days is sparse [2]. This is a report of 30- and 90-day mortality after TBC at a large volume interventional pulmonary practice in the United States examined in relation to indices of baseline disease severity. Individual case elements that led to practice changes are described. These descriptions elucidate clinical features potentially portending an increased risk of poor outcome.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Pannu has nothing to disclose.Conflict of interest: Lance Roller has nothing to disclose.Conflict of interest: Dr. Maldonado reports grants from ERBE research funding, outside the submitted work.Conflict of interest: Dr. Lentz has nothing to disclose.Conflict of interest: Heidi Chen has nothing to disclose.Conflict of interest: Dr. Rickman has nothing to disclose. ER -