TY - JOUR T1 - Pectus excavatum is associated with sleep-related breathing disorders in children JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00524-2019 SP - 1900524 AU - Hiroo Wada AU - Manami Kimura AU - Ryutaro Shirahama AU - Ai Ikeda AU - David Gozal AU - Takeshi Tanigawa Y1 - 2019/01/01 UR - http://erj.ersjournals.com/content/early/2019/06/19/13993003.00524-2019.abstract N2 - Funnel chest or pectus excavatum (PE), is a chest wall deformity, and its major causes include hereditary connective tissue disorders and neuromuscular diseases [1, 2]. In addition, PE is more likely to occur in the context of disorders associated with upper airway obstruction, including adenotonsillar hypertrophy, and bronchomalacia [3], suggesting that potential causal effects. Indeed, repeated increased intrathoracic negative pressure swings in children with sleep apnoea could lead to PE, although only limited evidence exists to this effect. We hypothesised that sleep-related breathing disorders (SRBD) is among the causes of PE in children, and therefore examined the association between PE and SRDB in children.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Wada has nothing to disclose.Conflict of interest: Dr. Kimura has nothing to disclose.Conflict of interest: Dr. Shirahama has nothing to disclose.Conflict of interest: Dr. Ikeda has nothing to disclose.Conflict of interest: Dr. Gozal has nothing to disclose.Conflict of interest: Dr. Tanigawa has nothing to disclose. ER -