RT Journal Article
SR Electronic
T1 Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1802058
DO 10.1183/13993003.02058-2018
VO 53
IS 5
A1 Vanessa M. McDonald
A1 James Fingleton
A1 Alvar Agusti
A1 Sarah A. Hiles
A1 Vanessa L. Clark
A1 Anne E. Holland
A1 Guy B. Marks
A1 Philip P. Bardin
A1 Richard Beasley
A1 Ian D. Pavord
A1 Peter A.B. Wark
A1 Peter G. Gibson
A1 ,
YR 2019
UL http://erj.ersjournals.com/content/53/5/1802058.abstract
AB “Treatable traits” have been proposed as a new paradigm for the management of airway diseases, particularly complex disease, which aims to apply personalised medicine to each individual to improve outcomes. Moving new treatment approaches from concepts to practice is challenging, but necessary. In an effort to accelerate progress in research and practice relating to the treatable traits approach, the Treatable Traits Down Under International Workshop was convened in Melbourne, Australia in May 2018. Here, we report the key concepts and research questions that emerged in discussions during the meeting. We propose a programme of research that involves gaining international consensus on candidate traits, recognising the prevalence of traits, and identifying a potential hierarchy of traits based on their clinical impact and responsiveness to treatment. We also reflect on research methods and designs that can generate new knowledge related to efficacy of the treatable traits approach and consider multidisciplinary models of care that may aid its implementation into practice.Treatable traits are proposed as an approach to personalised medicine for people with airway diseases. This review highlights the essential components of this approach, and how we can progress research and implementation. http://ow.ly/gV9I30nMHQ1