TY - JOUR T1 - Exercising our options: comparing effects of exercise and positive expiratory pressure on mucociliary clearance JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00510-2019 VL - 53 IS - 4 SP - 1900510 AU - Scott H. Donaldson Y1 - 2019/04/01 UR - http://erj.ersjournals.com/content/53/4/1900510.abstract N2 - Cystic fibrosis (CF) lung disease is characterised by defective clearance of airway secretions that are hyperconcentrated, viscous, and serve as the nidus of chronic polymicrobial infection. The pathophysiological events that link CFTR channel dysfunction to mucus obstruction of airways are multifactorial, complex and an ongoing source of debate [1, 2]. Despite the availability of multiple “symptomatic therapies” that target mucus retention (hypertonic saline, mannitol, dornase alfa and mucolytics), mechanical clearance of airway secretions has continued to be a cornerstone of treatment across patient populations [3]. Indeed, even with the emergence of highly effective CFTR modulators, which target the basic CF defect and improve mucociliary clearance [4], mechanical airway clearance techniques (ACT) are typically continued.This editorial discusses the paper by Dwyer and co-workers: “Effects of exercise and airway clearance (PEP) on mucus clearance in cystic fibrosis”, including implications for clinical care and future research http://ow.ly/3P6X30o6EaK ER -