RT Journal Article
SR Electronic
T1 Serum levels of hyaluronic acid are associated with COPD severity and predict survival
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1801183
DO 10.1183/13993003.01183-2018
VO 53
IS 3
A1 Eleni Papakonstantinou
A1 Ioannis Bonovolias
A1 Michael Roth
A1 Michael Tamm
A1 Desiree Schumann
A1 Florent Baty
A1 Renaud Louis
A1 Branislava Milenkovic
A1 Wim Boersma
A1 Bram Stieltjes
A1 Konstantinos Kostikas
A1 Francesco Blasi
A1 Joachim G. Aerts
A1 Gernot G.U. Rohde
A1 Alicia Lacoma
A1 Antoni Torres
A1 Tobias Welte
A1 Daiana Stolz
YR 2019
UL http://erj.ersjournals.com/content/53/3/1801183.abstract
AB Hyaluronic acid (HA) and its degradation products play an important role in lung pathophysiology and airway remodelling in chronic obstructive pulmonary disease (COPD).We investigated if HA and its degrading enzyme hyaluronidase (HYAL)-1 are associated with COPD severity and outcome.Serum HA was assessed in a discovery cohort of 80 COPD patients at stable state and exacerbations. HA, HYAL-1 and HYAL-1 enzymatic activity were evaluated at stable state, exacerbations and 4 weeks after exacerbations in 638 COPD patients from the PROMISE validation cohort.In the discovery cohort, serum HA was higher at exacerbations compared with the stable state (p=0.015). In the validation cohort, HA was higher at moderate and severe exacerbations than at baseline (p<0.001), and remained higher after 4 weeks (p<0.001). HA was strongly predictive for overall survival since it was associated with time to death (p<0.001) independently of adjusted Charlson score, annual exacerbation rate and BODE (body mass, airflow obstruction, dyspnoea, exercise capacity) index. Serum HYAL-1 was increased at moderate (p=0.004) and severe (p=0.003) exacerbations, but decreased after 4 weeks (p<0.001). HYAL-1 enzymatic activity at stable state was inversely correlated with FEV1 % pred (p=0.034) and survival time (p=0.017).Serum HA is associated with COPD severity and predicts overall survival. Degradation of HA is associated with airflow limitation and impairment of lung function.Serum hyaluronic acid (HA) is associated with COPD severity, outcome and predicts overall survival. Enzymatic degradation of HA is associated with airflow limitation and impairment of lung function. http://ow.ly/COl830n2IcQ