TY - JOUR T1 - New insights into immunological responses to infection in bronchiectasis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02395-2018 VL - 53 IS - 2 SP - 1802395 AU - Michal Shteinberg AU - Anand Shah AU - J. Stuart Elborn Y1 - 2019/02/01 UR - http://erj.ersjournals.com/content/53/2/1802395.abstract N2 - Infection and inflammation drive the pathogenesis of lung injury in bronchiectasis. The “vicious cycle” hypothesis suggests that infection leads to inflammation, which in turn disrupts normal bronchial structure and mucociliary clearance. This stimulates excessive mucus production which fosters bronchial infection causing further airway and parenchymal injury and further amplifying the intensity of inflammation.Immunological responses to infection are impaired in bronchiectasis. Autoimmune antibodies to neutrophil components may impair clearance of Pseudomonas and thus contribute to the chronicity of infection. http://ow.ly/MGm230n4AEF ER -