PT  - JOURNAL ARTICLE
AU  - Diane M. Gray
AU  - Dorottya Czovek
AU  - Lauren McMillan
AU  - Lidija Turkovic
AU  - Jacob A.M. Stadler
AU  - Anessa Vanker
AU  - Bence L. Radics
AU  - Zoltán Gingl
AU  - Graham L. Hall
AU  - Peter D. Sly
AU  - Heather J. Zar
AU  - Zoltán Hantos
TI  - Intra-breath measures of respiratory mechanics in healthy African infants detect risk of respiratory illness in early life
AID  - 10.1183/13993003.00998-2018
DP  - 2019 Feb 01
TA  - European Respiratory Journal
PG  - 1800998
VI  - 53
IP  - 2
4099  - http://erj.ersjournals.com/content/53/2/1800998.short
4100  - http://erj.ersjournals.com/content/53/2/1800998.full
SO  - Eur Respir J2019 Feb 01; 53
AB  - Lower respiratory tract illness (LRTI) is a leading cause of mortality and morbidity in children. Sensitive and noninvasive infant lung function techniques are needed to measure risk for and impact of LRTI on lung health. The objective of this study was to investigate whether lung function derived from the intra-breath forced oscillation technique (FOT) was able to identify healthy infants at risk of LRTI in the first year of life.Lung function was measured with the novel intra-breath FOT, in 6-week-old infants in a South African birth cohort (Drakenstein Child Health Study). LRTI during the first year was confirmed by study staff. The association between baseline lung function and LRTI was assessed with logistic regression and odds ratios determined using optimal cut-off values.Of the 627 healthy infants with successful lung function testing, 161 (24%) had 238 LRTI episodes subsequently during the first year. Volume dependence of respiratory resistance (ΔR) and reactance (ΔX) was associated with LRTI. The predictive value was stronger if LRTI was recurrent (n=50 (31%): OR 2.5, ΔX), required hospitalisation (n=38 (16%): OR 5.4, ΔR) or was associated with wheeze (n=87 (37%): OR 3.9, ΔX).Intra-breath FOT can identify healthy infants at risk of developing LRTI, wheezing or severe illness in the first year of life.Novel measurements of respiratory mechanics are feasible in infants in a community setting and able to detect changes in lung function in healthy infants associated with increased risk of subsequent LRTI in infancy http://ow.ly/IUKk30mCfi3