RT Journal Article
SR Electronic
T1 Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1801900
DO 10.1183/13993003.01900-2018
VO 53
IS 1
A1 Vonk Noordegraaf, Anton
A1 Chin, Kelly Marie
A1 Haddad, François
A1 Hassoun, Paul M.
A1 Hemnes, Anna R.
A1 Hopkins, Susan Roberta
A1 Kawut, Steven Mark
A1 Langleben, David
A1 Lumens, Joost
A1 Naeije, Robert
YR 2019
UL https://publications.ersnet.org//content/53/1/1801900.abstract
AB The function of the right ventricle determines the fate of patients with pulmonary hypertension. Since right heart failure is the consequence of increased afterload, a full physiological description of the cardiopulmonary unit consisting of both the right ventricle and pulmonary vascular system is required to interpret clinical data correctly. Here, we provide such a description of the unit and its components, including the functional interactions between the right ventricle and its load. This physiological description is used to provide a framework for the interpretation of right heart catheterisation data as well as imaging data of the right ventricle obtained by echocardiography or magnetic resonance imaging. Finally, an update is provided on the latest insights in the pathobiology of right ventricular failure, including key pathways of molecular adaptation of the pressure overloaded right ventricle. Based on these outcomes, future directions for research are proposed.State of the art and research perspectives in pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension with theoretical and practical aspects http://ow.ly/18v830mgLiP