PT - JOURNAL ARTICLE AU - Nathan, Steven D. AU - Barbera, Joan A. AU - Gaine, Sean P. AU - Harari, Sergio AU - Martinez, Fernando J. AU - Olschewski, Horst AU - Olsson, Karen M. AU - Peacock, Andrew J. AU - Pepke-Zaba, Joanna AU - Provencher, Steeve AU - Weissmann, Norbert AU - Seeger, Werner TI - Pulmonary hypertension in chronic lung disease and hypoxia AID - 10.1183/13993003.01914-2018 DP - 2019 Jan 01 TA - European Respiratory Journal PG - 1801914 VI - 53 IP - 1 4099 - https://publications.ersnet.org//content/53/1/1801914.short 4100 - https://publications.ersnet.org//content/53/1/1801914.full SO - Eur Respir J2019 Jan 01; 53 AB - Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Haemodynamic evaluation of PH severity should be contextualised within the extent of the underlying lung disease, which is best gauged through a combination of physiological and imaging assessment. Who, when, if and how to screen for PH will be addressed in this article, as will the current state of knowledge with regard to the role of treatment with pulmonary vasoactive agents. Although such therapy cannot be endorsed given the current state of findings, future studies in this area are strongly encouraged.State of the art and research perspectives in pulmonary hypertension in chronic lung disease and hypoxia http://ow.ly/XcW730meWxy