PT  - JOURNAL ARTICLE
AU  - A. Vejen Hansen
AU  - Z. Ali
AU  - S.S. Malchau
AU  - J. Blafoss
AU  - A. Pinborg
AU  - C.S. Ulrik
TI  - Fertility treatment among women with asthma - A case-control study of 3689 women with live births
AID  - 10.1183/13993003.00597-2018
DP  - 2018 Jan 01
TA  - European Respiratory Journal
PG  - 1800597
4099  - http://erj.ersjournals.com/content/early/2018/11/15/13993003.00597-2018.short
4100  - http://erj.ersjournals.com/content/early/2018/11/15/13993003.00597-2018.full
AB  - Asthma has been linked with prolonged time to pregnancy. Our aim was to explore a possible association between asthma and need for fertility treatment among women with live births.All women enrolled in the Management of Asthma during Pregnancy (MAP) program at Hvidovre Hospital (HH), Denmark, (cases) were each matched with the three consecutive women giving birth at HH (controls). Information from the Danish National Assisted Reproductive Technology registry was cross-linked with the Danish Medical Birth registry to identify live births. The primary outcome of interest was births following fertility treatment.Our sample comprised pregnancies from asthmatic (n=932, cases) and non-asthmatic (n=2757, controls) mothers (n=932), with 12% (n=114) and 8% (n=212), respectively, having had fertility treatment (OR 1.67, 95% CI 1.32–2.13, p<0.001). This association remained statistically significant after adjusting for confounders, incl. BMI (OR 1.31, 95% CI 1.00–1.70, p=0.047). In women ≥35 years, it was 25% (n=63) and 13% (n=82) of cases and controls, respectively, (OR 2.12, 95% CI 1.47–3.07, p<0.001), which also remained statistically significant after adjusting for confounders (OR 1.65, 95% CI (1.11–2.46), p=0.013).A higher proportion of the births from asthmatic mothers, compared to non-asthmatic mothers, involved fertility treatment, not least among women aged 35 years and older.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Ali has nothing to disclose.Conflict of interest: Dr. Malchau has nothing to disclose.Conflict of interest: Dr. Blafoss has nothing to disclose.Conflict of interest: Dr. Pinborg has nothing to disclose.Conflict of interest: Dr. Ulrik has nothing to disclose.Conflict of interest: Dr. Hansen has nothing to disclose.