RT Journal Article
SR Electronic
T1 Multiple breath washout is not useful in infants with bronchopulmonary dysplasia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4658
DO 10.1183/13993003.congress-2018.PA4658
VO 52
IS suppl 62
A1 Bas Ikizoglu, Nilay
A1 De Jong, Laura
A1 Karadag, Bulent
A1 Reiss, Irwin
A1 Duijts, Liesbeth
A1 Kroon, Andre
A1 Van Mastrigt, Esther
A1 Tiddens, Harm
A1 Ersu, Refika
A1 Pijnenburg, Marielle
YR 2018
UL http://erj.ersjournals.com/content/52/suppl_62/PA4658.abstract
AB Introduction: Children with bronchopulmonary dysplasia (BPD) have an increased risk for persistent structural and functional lung abnormalities. The multiple breath washout (MBW) test assesses efficiency of ventilation distribution and the lung clearance index (LCI) is considered a sensitive marker of ventilation inhomogeneity.Aim: To determine LCI and functional residual capacity (FRC) in infants with BPD and assess the correlations of LCI and FRC with lung structure and clinical parameters. We hypothesized that LCI would be elevated in infants with BPD and would correlate with structural changes.Methods: Preterm infants born ≤32 weeks gestational age (GA) with BPD were included. Demographics and clinical parameters were obtained from medical records. LCI and FRC were measured by MBW. Lung structure was assessed on chest CT with the PRAGMA-BPD scoring system. Volumes and percentages of regions with normal appearance, low attenuation, high attenuation and bronchial thickening were determined.Results: 15 infants with a median corrected age [IQR] of 7.0 [2.5] months were included. Median GA was 26.9 [1.3] weeks and birth weight was 907.8 [240] g. 14 infants had severe and one had mild BPD. Mean LCI was 7.2±0.7 and FRC was 162±52 ml. Only in 3 patients MBW was abnormal. Architectural distortion was present in all CTs. Median total lung volume was 238,7 [92.9] ml and healthy lung volume was 226,7 [108] ml. LCI and FRC did not correlate with lung volumes on CT and architectural distortion. FRC % predicted strongly correlated with GA (r=0.726, p<0.01), LCI did not correlate with any clinical parameters.Conclusion: LCI and FRC are not useful in the follow-up of patients with BPD.FootnotesCite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA4658.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).