TY - JOUR T1 - Domestic exposure to irritant cleaning agents and asthma in women JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2018.PA3919 VL - 52 IS - suppl 62 SP - PA3919 AU - Pierre Lemire AU - Orianne Dumas AU - Sebastien Chanoine AU - Sofia Temam AU - Gianluca Severi AU - Marie-Christine Boutron-Ruault AU - Jan-Paul Zock AU - Valerie Siroux AU - Raphaelle Varraso AU - Nicole Le Moual Y1 - 2018/09/15 UR - http://erj.ersjournals.com/content/52/suppl_62/PA3919.abstract N2 - Background: The adverse association between domestic exposure to cleaning agents, especially in spray form, and asthma is now well documented in the literature. However, data on domestic exposure to irritant cleaning agents are sparse.Aims: To investigate associations between usual irritant domestic cleaning products and current asthma, in a large cohort of elderly women.Methods: In a nested case-control study on asthma (Asthma-E3N, 2011-2013, n=19404, response rate: 92%; ever asthma: 33%), women completed standardized questionnaires on asthma and frequency of use of domestic cleaning products, especially four well-identified irritants (bleach, ammonia, decalcifiers, other acids). Associations between use of such irritants and current asthma were adjusted for age, smoking status, body mass index (BMI) and education level.Results: The 12758 women included in the analysis were on average 70 years old (current smokers: 4%, BMI≥ 25: 29%, low education: 11%, current asthma: 23%). No association was found between weekly use of bleach alone and current asthma (OR 95%CI: 1.09[0.97-1.21]). However, a strong association was observed for concomitant weekly use of several cleaning agents (p trend<0.0001; at least 3 agents: 2.14[1.58-2.90]). Specifically, significant associations were found for concomitant use of ammonia and bleach (1.89[1.17-3.03]) or more generally of bleach and at least one of the other irritants (1.31[1.13-1.52]). Results were similar after additional adjustment for use of cleaning sprays.Conclusions: Results suggested an increased risk of current asthma with use of multiple irritant cleaning agents at home. In further investigations, we will more specifically examine their associations with non-allergic asthma.FootnotesCite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA3919.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -