@article {LemirePA3919, author = {Pierre Lemire and Orianne Dumas and Sebastien Chanoine and Sofia Temam and Gianluca Severi and Marie-Christine Boutron-Ruault and Jan-Paul Zock and Valerie Siroux and Raphaelle Varraso and Nicole Le Moual}, title = {Domestic exposure to irritant cleaning agents and asthma in women}, volume = {52}, number = {suppl 62}, elocation-id = {PA3919}, year = {2018}, doi = {10.1183/13993003.congress-2018.PA3919}, publisher = {European Respiratory Society}, abstract = {Background: The adverse association between domestic exposure to cleaning agents, especially in spray form, and asthma is now well documented in the literature. However, data on domestic exposure to irritant cleaning agents are sparse.Aims: To investigate associations between usual irritant domestic cleaning products and current asthma, in a large cohort of elderly women.Methods: In a nested case-control study on asthma (Asthma-E3N, 2011-2013, n=19404, response rate: 92\%; ever asthma: 33\%), women completed standardized questionnaires on asthma and frequency of use of domestic cleaning products, especially four well-identified irritants (bleach, ammonia, decalcifiers, other acids). Associations between use of such irritants and current asthma were adjusted for age, smoking status, body mass index (BMI) and education level.Results: The 12758 women included in the analysis were on average 70 years old (current smokers: 4\%, BMI>= 25: 29\%, low education: 11\%, current asthma: 23\%). No association was found between weekly use of bleach alone and current asthma (OR 95\%CI: 1.09[0.97-1.21]). However, a strong association was observed for concomitant weekly use of several cleaning agents (p trend\<0.0001; at least 3 agents: 2.14[1.58-2.90]). Specifically, significant associations were found for concomitant use of ammonia and bleach (1.89[1.17-3.03]) or more generally of bleach and at least one of the other irritants (1.31[1.13-1.52]). Results were similar after additional adjustment for use of cleaning sprays.Conclusions: Results suggested an increased risk of current asthma with use of multiple irritant cleaning agents at home. In further investigations, we will more specifically examine their associations with non-allergic asthma.FootnotesCite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA3919.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/52/suppl_62/PA3919}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }