RT Journal Article SR Electronic T1 Long-term air pollution exposure is associated with sick leave 20 years later JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP OA5182 DO 10.1183/13993003.congress-2018.OA5182 VO 52 IS suppl 62 A1 Ane Johannessen A1 Ingrid Nordeide Kuiper A1 Simone Accordini A1 Randi Jacobsen Bertelsen A1 Bertil Forsberg A1 Thorarinn Gislason A1 Joachim Heinrich A1 Mathias Holm A1 Rain Jögi A1 Jorunn Kirkeleit A1 Andrei Malinovschi A1 Alessandro Marcon A1 Iana Markevych A1 Anna Oudin A1 Vivi Schlünssen A1 Torben Sigsgaard A1 Cecilie Svanes A1 Kjell Torén A1 Christer Janson YR 2018 UL http://erj.ersjournals.com/content/52/suppl_62/OA5182.abstract AB Background: Little is known on outdoor air pollution in a long-term perspective and societal costs such as sick leave. In the Nordic countries, recent pollution health impact assessments have had to rely on outdated studies.Aims: To investigate if air pollution exposure is associated with sick leave 20 years later.Methods: We analysed self-reported sick leave (all-cause and respiratory) in 7 466 subjects from Bergen, Gothenburg, Umea, Uppsala in the RHINE3 study in 2010-12. Home addresses were geocoded and linked to annual average concentrations of PM2.5, PM10 and NO2 at RHINE3, 10 years earlier and 20 years earlier, using existing land-use regression (LUR) models. We performed multilevel logistic regression clustered by centre, and adjusted for sex, smoking, education and previous health-related workplace change.Results: Age range in RHINE3 was 40-66 yrs, 34% and 4% reported all-cause and respiratory sick leave during the last year. In the adjusted analyses all-cause sick leave was associated with PM2.5 20 years earlier (OR per interquartile range (IQR) difference (2.6 µg/m³) 1.12 (95%CI 1.01, 1.24)), and borderline with NO2 (OR per IQR diff (8.1 µg/m³) 1.09 (95%CI 0.99, 1.19)). Respiratory sick leave was associated with PM10 20 years earlier (OR per IQR diff (3.92 µg/m³) 1.54 (95%CI 1.06, 2.25)), and borderline with PM2.5 (OR per IQR diff 1.31 (95%CI 0.97, 1.76)). Pollution exposures at present as well as 10 years earlier were not significantly associated with sick leave.Conclusions: Air pollution exposure in a general population is associated with sick leave in a 20-year perspective. Our findings suggest that even low air pollution levels such as in Northern Europe have societal costs over time.FootnotesCite this article as: European Respiratory Journal 2018 52: Suppl. 62, OA5182.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).