%0 Journal Article %A Ayse Gul Zamani %A Adil Zamani %A Celalettin Korkmaz %A Sebnem Yosunkaya %A Mahmut Selman Yildirim %T Variants of genes related to cardiovascular disease in patients with pulmonary thromboembolism %D 2018 %R 10.1183/13993003.congress-2018.OA3800 %J European Respiratory Journal %P OA3800 %V 52 %N suppl 62 %X Background: Atherosclerosis and venous thrombosis are the two major manifestations of cardiovascular disease (CVD).Objectives: To evaluate the genetic variants associated with CVD including angiotensin converting enzyme (ACE): 287 bp insertion and deletion (I/D), platelet receptor GPIIIa (ITGB3): c.176T>C, fibrinogen beta chain (FGB): c.-463G>A, factor XIII (F13A1): V34L, angiotensin (AGT): c.803T>C, angiotensin II type 1 receptor (ATGR1): A1166C , cystathionine beta-synthase (CBS): 844ins68 in patients with pulmonary thromboembolism.Methods: The study included 58 patients (25 males, and 33 females). The patients were divided into two age groups: group A < 45 years of age (17 patients) and group B ≥ 45 years of age (41 patients). CVD-associated genes variants were genotyped by multiplex allele specific PCR amplification.Results: A statistically significant difference was found between the DD and II genotypes (p<0.01; OR=10.49; 95% C.I.=[6.18-17.79], DD+ID and II genotypes (p<0.01; OR=0.148 ; 95% C.I.=[0.035-0.623]), and DD and ID genotypes (p<0.01; OR=0.185 ; 95% C.I.=[0.046-0.743]) in group B than in group A. The frequencies of other genetic variants showed similar frequencies in all comparisons.Conclusion: The present study demonstrated that the ACE ID and DD genotypes are associated with an increased risk of pulmonary thromboembolism in patients older than 45 years of age.FootnotesCite this article as: European Respiratory Journal 2018 52: Suppl. 62, OA3800.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). %U