RT Journal Article
SR Electronic
T1 Physical activity as a moderator for obstructive sleep apnoea and cardiometabolic risk in the EPISONO study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1701972
DO 10.1183/13993003.01972-2017
VO 52
IS 4
A1 Marcos Mônico-Neto
A1 Hanna Karen Moreira Antunes
A1 Ronaldo Vagner Thomatieli dos Santos
A1 Vânia D'Almeida
A1 Altay Alves Lino de Souza
A1 Lia Rita Azeredo Bittencourt
A1 Sergio Tufik
YR 2018
UL http://erj.ersjournals.com/content/52/4/1701972.abstract
AB Obstructive sleep apnoea (OSA) is positively associated with cardiometabolic diseases; however, high levels of physical activity could decrease the incidence of OSA and associated comorbidities.In this study we aimed to examine the incidence of OSA in relation to physical activity, and its role as a protective factor in individuals with OSA on the incidence of cardiometabolic diseases, in an 8–9-year follow-up study. We analysed data of 658 volunteers from the São Paulo Epidemiologic Sleep Study (EPISONO), a cohort study of individuals aged 20–80 years, collected through polysomnography, the International Physical Activity Questionnaire and an assessment of cardiometabolic profile.Active subjects had a lower risk of developing OSA compared with nonactive subjects (relative risk 0.877, 95% CI 0.296–0.855) and there was a reduced risk of developing type 2 diabetes mellitus in active/apnoeic subjects (relative risk 0.493, 95% CI 0.252–0.961) compared with nonactive subjects. Metabolic equivalent was negatively associated to cardiometabolic markers, such as C-reactive protein (exp(B)=0.720; p=0.001), interleukin-6 (exp(B)=0.991; p=0.03), insulin (exp(B)=0.982; p=0.03), triglycerides (exp(B)=0.997; p<0.001), homeostasis model assessment for insulin resistance (exp(B)≤0.946; p<0.024), quantitative insulin sensitivity check index (exp(B)=992.4; p<0.001) and mean arterial pressure (exp(B)=0.987; p=0.001).Physical activity was a protective factor against type 2 diabetes mellitus in apnoeic individuals; moreover, being active reduced the risk of developing OSA and was associated with a better cardiometabolic profile.Physical activity reduces OSA incidence and protects against cardiometabolic diseases http://ow.ly/NxLh30leRPC