RT Journal Article
SR Electronic
T1 Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1800504
DO 10.1183/13993003.00504-2018
VO 52
IS 3
A1 Zuelma A. Contreras
A1 Zhanghua Chen
A1 Theano Roumeliotaki
A1 Isabella Annesi-Maesano
A1 Nour Baïz
A1 Andrea von Berg
A1 Anna Bergström
A1 Sarah Crozier
A1 Liesbeth Duijts
A1 Sandra Ekström
A1 Esben Eller
A1 Maria P. Fantini
A1 Henrik Fomsgaard Kjaer
A1 Francesco Forastiere
A1 Beatrix Gerhard
A1 Davide Gori
A1 Margreet W. Harskamp-van Ginkel
A1 Joachim Heinrich
A1 Carmen Iñiguez
A1 Hazel Inskip
A1 Thomas Keil
A1 Manolis Kogevinas
A1 Susanne Lau
A1 Irina Lehmann
A1 Dieter Maier
A1 Evelien R. van Meel
A1 Monique Mommers
A1 Mario Murcia
A1 Daniela Porta
A1 Henriëtte A. Smit
A1 Marie Standl
A1 Nikos Stratakis
A1 Jordi Sunyer
A1 Carel Thijs
A1 Maties Torrent
A1 Tanja G.M. Vrijkotte
A1 Alet H. Wijga
A1 Kiros Berhane
A1 Frank Gilliland
A1 Leda Chatzi
YR 2018
UL http://erj.ersjournals.com/content/52/3/1800504.abstract
AB The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3–4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3–4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18–2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31–3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08–2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.Children who have asthma or wheezing in early childhood may be at a higher risk of developing obesity http://ow.ly/HfKw30lhF3X