TY - JOUR T1 - Does early-onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00504-2018 SP - 1800504 AU - Zuelma A. Contreras AU - Zhanghua Chen AU - Theano Roumeliotaki AU - Isabella Annesi-Maesano AU - Nour Baïz AU - Andrea von Berg AU - Anna Bergström AU - Sarah Crozier AU - Liesbeth Duijts AU - Sandra Ekström AU - Esben Eller AU - Maria P. Fantini AU - Henrik Fomsgaard Kjaer AU - Francesco Forastiere AU - Beatrix Gerhard AU - Davide Gori AU - Margreet W. Harskamp-van Ginkel AU - Joachim Heinrich AU - Carmen Iñiguez AU - Hazel Inskip AU - Thomas Keil AU - Manolis Kogevinas AU - Susanne Lau AU - Irina Lehmann AU - Dieter Maier AU - Evelien R. van Meel AU - Monique Mommers AU - Mario Murcia AU - Daniela Porta AU - Henriëtte A Smit AU - Marie Standl AU - Nikos Stratakis AU - Jordi Sunyer AU - Carel Thijs AU - Maties Torrent AU - Tanja GM Vrijkotte AU - Alet H Wijga AU - Kiros Berhane AU - Frank Gilliland AU - Leda Chatzi Y1 - 2018/01/01 UR - http://erj.ersjournals.com/content/early/2018/08/02/13993003.00504-2018.abstract N2 - The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, the Netherlands, Spain, Sweden, and United Kingdom. We followed non-obese children at 3–4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing, and allergic rhinitis were assessed up to 3–4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR): 1.66, 95% CI: 1.18, 2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma), exhibited a higher risk for obesity (aHR: 1.98, 95% CI: 1.31, 3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR: 1.51, 95% CI: 1.08, 2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Contreras has nothing to disclose.Conflict of interest: Dr. Chen has nothing to disclose.Conflict of interest: Mrs. Roumeliotaki has nothing to disclose.Conflict of interest: Dr. Annesi-Maesano has nothing to disclose.Conflict of interest: Dr. Baiz has nothing to disclose.Conflict of interest: Dr. von Berg has nothing to disclose.Conflict of interest: Dr. Bergström has nothing to disclose.Conflict of interest: Dr. Crozier has nothing to disclose.Conflict of interest: Dr. Duijts reports grants from European Union's Horizon 2020 co-funded programme ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL) , grants from European Union's Horizon 2020 , during the conduct of the study.Conflict of interest: Dr. Ekström has nothing to disclose.Conflict of interest: Dr. Eller has nothing to disclose.Conflict of interest: Dr. Fantini has nothing to disclose.Conflict of interest: Dr. Kjaer has nothing to disclose.Conflict of interest: Dr. FORASTIERE has nothing to disclose.Conflict of interest: Dr. Gerhard reports grants from EU FP7, during the conduct of the study.Conflict of interest: Dr. Gori has nothing to disclose.Conflict of interest: Dr. Harskamp-van Ginkel has nothing to disclose.Conflict of interest: Dr. Heinrich has nothing to disclose.Conflict of interest: Dr. Iñiguez has nothing to disclose.Conflict of interest: Dr. Inskip reports grants from UK Medical Research Council, grants from British Heart Foundation, grants from UK Food Standards Agency, grants from British Lung Foundation, grants from Arthritis Research UK, grants from NIHR Southampton Biomedical Research Centre, grants from European Union's Seventh Framework Programme (FP7/2007-2013), project EarlyNutrition under grant agreement n°289346, during the conduct of the study; and Members of her team have received funding from Nestec, Abbott Nutrition and Danone Nutricia for various projects to which she is linked, but she has received no direct funding herself..Conflict of interest: Dr. Keil has nothing to disclose.Conflict of interest: Dr. Kogevinas has nothing to disclose.Conflict of interest: Dr. Lau reports grants and personal fees from Symbiopharm , grants and personal fees from Allergopharma, personal fees and non-financial support from DBV, personal fees from ALK, non-financial support from Boehringer, non-financial support from Merck, outside the submitted work.Conflict of interest: Dr. Lehmann has nothing to disclose.Conflict of interest: Dr. Maier reports grants from European Commission, during the conduct of the study.Conflict of interest: Dr. van Meel has nothing to disclose.Conflict of interest: Dr. Mommers has nothing to disclose.Conflict of interest: Dr. Murcia has nothing to disclose.Conflict of interest: Dr. PORTA has nothing to disclose.Conflict of interest: Dr. Smit has nothing to disclose.Conflict of interest: Dr. Standl has nothing to disclose.Conflict of interest: Dr. Stratakis has nothing to disclose.Conflict of interest: Dr. Sunyer has nothing to disclose.Conflict of interest: Dr. Thijs has nothing to disclose.Conflict of interest: Dr. Torrent has nothing to disclose.Conflict of interest: Dr. Vrijkotte has nothing to disclose.Conflict of interest: Dr. Wijga has nothing to disclose.Conflict of interest: Dr. Berhane has nothing to disclose.Conflict of interest: Dr. Gilliland has nothing to disclose.Conflict of interest: Dr. Chatzi has nothing to disclose. 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