TY - JOUR T1 - Impact of sleep alterations on weaning duration of mechanically ventilated patients: how much is bad? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00979-2018 VL - 52 IS - 1 SP - 1800979 AU - Arnaud W. Thille AU - Rémi Coudroy AU - Faustine Reynaud AU - Damien Marie AU - Stéphanie Barrau AU - Ludivine Rousseau AU - Christophe Rault AU - Véronique Diaz AU - Jean-Claude Meurice AU - Jean-Pierre Frat AU - René Robert AU - Xavier Drouot Y1 - 2018/07/01 UR - http://erj.ersjournals.com/content/52/1/1800979.abstract N2 - Sleep is markedly altered in intensive care unit (ICU) patients under mechanical ventilation [1–4]. Sleep in these patients is fragmented by numerous arousals and awakenings and mainly comprises light sleep. The deep sleep allowing physical restoration and the rapid eye movement (REM) sleep allowing neurobehavioral restoration may completely disappear. In some ICU patients, normal sleep architecture may disappear and be replaced by electroencephalogram aspects suggesting atypical sleep [5–7]. Whereas it has been shown that sleep deprivation could alter physical and cognitive functions in animals [8], the potential deleterious effects of such sleep disturbances in critically ill patients are unknown.A strong relationship might exist between sleep and weaning from mechanical ventilation in the ICU, and sleep alterations may be an underexplored aspect of weaning difficulties http://ow.ly/TzQq30ktNB5 ER -