RT Journal Article
SR Electronic
T1 Tobacco smoke exposure in early life and adolescence in relation to lung function
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1702111
DO 10.1183/13993003.02111-2017
VO 51
IS 6
A1 Jesse D. Thacher
A1 Erica S. Schultz
A1 Jenny Hallberg
A1 Ulrika Hellberg
A1 Inger Kull
A1 Per Thunqvist
A1 Göran Pershagen
A1 Per M. Gustafsson
A1 Erik Melén
A1 Anna Bergström
YR 2018
UL http://erj.ersjournals.com/content/51/6/1702111.abstract
AB Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure and adolescent smoking on lung function at age 16 years.The BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology) birth cohort collected information on participants' tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16 years. Participants performed spirometry and impulse oscillometry (IOS) at age 16 years (n=2295).Exposure to maternal smoking during pregnancy was associated with reduced forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio of −1.1% (95% CI −2.0 to −0.2%). IOS demonstrated greater resistance at 5–20 Hz (R5–20) in participants exposed to maternal smoking during pregnancy. Adolescents who smoked had reduced FEV1/FVC ratios of −0.9% (95% CI −1.8 to −0.1%) and increased resistance of 6.5 Pa·L–1·s (95% CI 0.7 to 12.2 Pa·L–1·s) in R5–20. Comparable associations for FEV1/FVC ratio were observed for cotinine concentrations, using ≥12 ng·mL−1 as a cut-off for adolescent smoking.Maternal smoking during pregnancy was associated with lower FEV1/FVC ratios and increased airway resistance. In addition, adolescent smoking appears to be associated with reduced FEV1/FVC ratios and increased peripheral airway resistance.Maternal smoking in utero and teenage smoking are associated with indices of airway obstruction at age 16 years http://ow.ly/NwF030jFS2W