RT Journal Article
SR Electronic
T1 Long-term bedaquiline-related treatment outcomes in patients with extensively drug-resistant tuberculosis from South Africa
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1800544
DO 10.1183/13993003.00544-2018
VO 51
IS 5
A1 Olatunde Olayanju
A1 Jason Limberis
A1 Aliasgar Esmail
A1 Suzette Oelofse
A1 Phindile Gina
A1 Elize Pietersen
A1 Mohammed Fadul
A1 Rob Warren
A1 Keertan Dheda
YR 2018
UL http://erj.ersjournals.com/content/51/5/1800544.abstract
AB Optimal treatment regimens for patients with extensively drug-resistant tuberculosis (XDR-TB) remain unclear. Long-term prospective outcome data comparing XDR-TB regimens with and without bedaquiline from an endemic setting are lacking.We prospectively followed-up 272 South African patients (49.3% HIV-infected; median CD4 count 169 cells·µL−1) with newly diagnosed XDR-TB between 2008 and 2017. Outcomes were compared between those who had not received bedaquiline (pre-2013; n=204) and those who had (post-2013; n=68; 80.9% received linezolid in addition).The 24-month favourable outcome rate was substantially better in the bedaquiline versus the non-bedaquiline group (66.2% (45 out of 68) versus 13.2% (27 out of 204); p<0.001). In addition, the bedaquiline group exhibited reduced 24-month rates of treatment failure (5.9% versus 26.0%; p<0.001) and default (1.5% versus 15.2%; p<0.001). However, linezolid was withdrawn in 32.7% (18 out of 55) of patients in the bedaquiline group because of adverse events. Admission weight >50 kg, an increasing number of anti-TB drugs and bedaquiline were independent predictors of survival (the bedaquiline survival effect remained significant in HIV-infected persons, irrespective of CD4 count).XDR-TB patients receiving a backbone of bedaquiline and linezolid had substantially better favourable outcomes compared to those not using these drugs. These data inform the selection of XDR-TB treatment regimens and roll-out of newer drugs in TB-endemic countries.Bedaquiline remarkably improved treatment-related outcomes in patients with extensively drug-resistant tuberculosis http://ow.ly/lYXG30kNsD5