PT - JOURNAL ARTICLE AU - Signe Vedel-Krogh AU - Børge G. Nordestgaard AU - Peter Lange AU - Jørgen Vestbo AU - Sune F. Nielsen TI - Blood eosinophil count and risk of pneumonia hospitalisations in individuals with COPD AID - 10.1183/13993003.00120-2018 DP - 2018 May 01 TA - European Respiratory Journal PG - 1800120 VI - 51 IP - 5 4099 - http://erj.ersjournals.com/content/51/5/1800120.short 4100 - http://erj.ersjournals.com/content/51/5/1800120.full SO - Eur Respir J2018 May 01; 51 AB - Blood eosinophil count in chronic obstructive pulmonary disease (COPD) is associated with higher exacerbation rate and favourable response to corticosteroids; however, frequent exacerbations and use of inhaled corticosteroids could elevate pneumonia risk. We tested the hypothesis that high blood eosinophil counts are associated with high risk of pneumonia in individuals with severe COPD from the general population.We included 7180 individuals with COPD from the Copenhagen General Population Study, including 643 with forced expiratory volume in 1 s (FEV1) <50% predicted between 2003 and 2011. All primary discharge diagnoses of pneumonia during follow-up were recorded.Among individuals with COPD and FEV1 <50% pred, the multivariable adjusted incidence rate ratio was 2.17 (95% CI 1.31–3.58) for pneumonia comparing individuals with blood eosinophil counts ≥0.34×109 cells·L−1 versus <0.34×109 cells·L−1. In individuals with clinical COPD, defined by recent exacerbation, ≥10 pack-years of smoking and FEV1 <70% pred, the corresponding risk was 4.52 (2.11–9.72). Risk of pneumonia did not differ by blood eosinophil count in individuals with COPD and FEV1 ≥50% pred.In individuals with COPD and FEV1 <50% pred, blood eosinophil count ≥0.34×109 cells·L−1 was associated with high risk of hospitalisation due to pneumonia.Eosinophilic COPD with severely impaired lung function is associated with high risk of pneumonia hospitalisations http://ow.ly/Tyl130jsi1D