TY - JOUR T1 - The effects of electronic cigarette vapour on the lung: direct comparison to tobacco smoke JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01661-2017 VL - 51 IS - 4 SP - 1701661 AU - Viktorija Reinikovaite AU - Ivan E. Rodriguez AU - Vijaya Karoor AU - Aline Rau AU - Becky B. Trinh AU - Frederic W-B. Deleyiannis AU - Laima Taraseviciene-Stewart Y1 - 2018/04/01 UR - http://erj.ersjournals.com/content/51/4/1701661.abstract N2 - Electronic cigarette (e-cigarette) usage in the USA has drastically increased in the past 5 years due to age restrictions on conventional cigarettes, aggressive marketing and a perception that e-cigarettes are a healthy alternative. E-cigarettes contain nicotine, water, glycerol, propylene glycol and optional flavouring. On inhalation, the device heats the ingredients into a vapour [1]. While tobacco cigarette smoke is known to cause deleterious effects on the cardiovascular system, angiogenesis and skin capillary perfusion by causing direct injury to blood vessel walls, increased platelet aggregation, microvascular thrombosis [2–4] and inflammation [5], the consequences of e-cigarette vapour exposure on the lung are still largely unexplored [6, 7]. Recently, Lerner et al. [8] reported that vapours produced by e-cigarettes and e-cigarette fluids with flavourings induced toxicity, oxidative stress and inflammatory response in human bronchial airway epithelial cells (H292) and fetal lung fibroblasts (HFL1) as well as mouse lung. Garcia-Arcos et al. [9] showed that the aerosolised nicotine-containing e-cigarette fluid increased airway hyperreactivity, distal airspace enlargement, mucin production, and cytokine and protease expression in mice, implying potential dangers of nicotine inhalation during e-cigarette use. The inflammatory response to e-cigarette use involved increased neutrophil activation and mucus production [10], and decreased mucociliary clearance [11]. In human embryonic and mouse neural stem cells, human pulmonary fibroblasts [12], and skin and lung cells [13], cytotoxicity of e-cigarette vapour was correlated with the number and concentration of chemicals used to flavour the fluids. We recently showed in the skin flap survival model in vivo that nicotine-containing e-cigarette vapour is just as harmful to the microcirculation as tobacco cigarette smoke [4].Electronic cigarettes are as toxic as tobacco cigarettes and can cause significant lung damage http://ow.ly/qT1l30ig1oR ER -