@article {Havet1702036, author = {Ana{\"\i}s Havet and Farid Zerimech and Margaux Sanchez and Val{\'e}rie Siroux and Nicole Le Moual and Bert Brunekreef and Morgane Stempfelet and Nino K{\"u}nzli and B{\'e}n{\'e}dicte Jacquemin and R{\'e}gis Matran and Rachel Nadif}, editor = {Siroux, V. and Demenais, F. and Pin, I. and Nadif, R. and Kauffmann, F. and Korobaeff, M. and Neukirch, F. and Annesi-Maesano, I. and Oryszczyn, M.P. and Le Moual, N. and Varraso, R. and Feingold, J. and Bouzigon, E. and Dizier, M.H. and Gut, I. and Lathrop, M. and Pison, C. and Ecochard, D. and Gormand, F. and Pacheco, Y. and Charpin, D. and Vervloet, D. and Bousquet, J. and Lockhart, A. and Matran, R. and Paty, E. and Scheinmann, P. and Grimfeld, A. and Just, J. and Hochez, J. and Ravault, C. and Chateigner, N. and Quentin, J.}, title = {Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study}, volume = {51}, number = {4}, elocation-id = {1702036}, year = {2018}, doi = {10.1183/13993003.02036-2017}, publisher = {European Respiratory Society}, abstract = {Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso.Cross-sectional analyses were conducted in 608 adults (39\% with current asthma) from the first follow-up of the French case{\textendash}control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter <=10 and <=2.5 {\textmu}m (PM10 and PM2.5), road traffic, and ozone (O3) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French Institute for the Environment) assessments. Models took account of city and familial dependence.The risk of current asthma increased with traffic intensity (adjusted (a)OR 1.09 (95\% CI 1.00{\textendash}1.18) per 5000 vehicles per day), with O3 exposure (aOR 2.04 (95\% CI 1.27{\textendash}3.29) per 10 {\textmu}g{\textperiodcentered}m-3) and with exhaled 8-iso concentration (aOR 1.50 (95\% CI 1.06{\textendash}2.12) per 1 pg{\textperiodcentered}mL-1). Among participants without asthma, exhaled 8-iso concentration increased with PM2.5 exposure (adjusted (a)β 0.23 (95\% CI 0.005{\textendash}0.46) per 5 {\textmu}g{\textperiodcentered}m-3), and decreased with O3 and O3-summer exposures (aβ -0.20 (95\% CI -0.39{\textendash} -0.01) and aβ -0.52 (95\% CI -0.77{\textendash} -0.26) per 10 {\textmu}g{\textperiodcentered}m-3, respectively).Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and asthma in adults.Exhaled 8-isoprostane concentration is associated with both outdoor air pollution and current asthma in adults http://ow.ly/esqN30iGCH3}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/51/4/1702036}, eprint = {https://erj.ersjournals.com/content/51/4/1702036.full.pdf}, journal = {European Respiratory Journal} }