RT Journal Article
SR Electronic
T1 Small airways dysfunction: the link between allergic rhinitis and allergic asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1701749
DO 10.1183/13993003.01749-2017
VO 51
IS 2
A1 Amaryllis Haccuria
A1 Alain Van Muylem
A1 Andrei Malinovschi
A1 Vi Doan
A1 Alain Michils
YR 2018
UL http://erj.ersjournals.com/content/51/2/1701749.abstract
AB Abnormal airway reactivity and overproduction of nitric oxide (NO) occurring in small airways have been found in asthma. If the “one airway, one disease” concept is consistent, such dysfunctions should also be detected in the peripheral airways of patients suffering from allergic rhinitis.We investigated whether peripheral airway reactivity and NO overproduction could be documented in distal airways in patients with allergic rhinitis. Exhaled NO fraction (FeNO) and the slope (S) of phase III of the single-breath washout test (SBWT) of helium (He) and sulfur hexafluoride (SF6) were measured in 31 patients with allergic asthma, 23 allergic rhinitis patients and 24 controls, before and after sputum induction. SBWT is sensitive to airway calibre change occurring in the lung periphery.The FeNO decrease was more significant in asthma and rhinitis than in controls (−55.1% and −50.0%, respectively, versus −40.8%) (p=0.007 and p=0.029, respectively). SSF6 and SHe increased in all groups. Change in SHe (ΔSHe) > ΔSSF6 was observed in rhinitis (p=0.004) and asthma (p<0.001), whereas ΔSSF6 = ΔSHe in controls (p=0.431).This study provides evidence of peripheral airway dysfunction in patients with allergic rhinitis quite similar to that described in asthma. Furthermore, a large proportion of the increased NO production reported in allergic rhinitis appears to originate in the peripheral airways.Abnormal airway reactivity and NO production are detected in peripheral airways of patients with allergic rhinitis http://ow.ly/hSwc30hdOm2