TY - JOUR T1 - Phenotypes of organ involvement in sarcoidosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00991-2017 VL - 51 IS - 1 SP - 1700991 AU - Jonas Christian Schupp AU - Sandra Freitag-Wolf AU - Elena Bargagli AU - Violeta Mihailović-Vučinić AU - Paola Rottoli AU - Aleksandar Grubanovic AU - Annegret Müller AU - Arne Jochens AU - Lukas Tittmann AU - Jasmin Schnerch AU - Carmela Olivieri AU - Annegret Fischer AU - Dragana Jovanovic AU - Snežana Filipovic AU - Jelica Videnovic-Ivanovic AU - Paul Bresser AU - René Jonkers AU - Kate O'Reilly AU - Ling-Pei Ho AU - Karoline I. Gaede AU - Peter Zabel AU - Anna Dubaniewicz AU - Ben Marshall AU - Robert Kieszko AU - Janusz Milanowski AU - Andreas Günther AU - Anette Weihrich AU - Martin Petrek AU - Vitezslav Kolek AU - Michael P. Keane AU - Sarah O'Beirne AU - Seamas Donnelly AU - Sigridur Olina Haraldsdottir AU - Kristin B. Jorundsdottir AU - Ulrich Costabel AU - Francesco Bonella AU - Benoît Wallaert AU - Christian Grah AU - Tatjana Peroš-Golubičić AU - Mauritio Luisetti AU - Zamir Kadija AU - Stefan Pabst AU - Christian Grohé AU - János Strausz AU - Martina Vašáková AU - Martina Sterclova AU - Ann Millar AU - Jiří Homolka AU - Alena Slováková AU - Yvonne Kendrick AU - Anjali Crawshaw AU - Wim Wuyts AU - Lisa Spencer AU - Michael Pfeifer AU - Dominique Valeyre AU - Venerino Poletti AU - Hubertus Wirtz AU - Antje Prasse AU - Stefan Schreiber AU - Michael Krawczak AU - Joachim Müller-Quernheim Y1 - 2018/01/01 UR - http://erj.ersjournals.com/content/51/1/1700991.abstract N2 - Sarcoidosis is a highly variable, systemic granulomatous disease of hitherto unknown aetiology. The GenPhenReSa (Genotype–Phenotype Relationship in Sarcoidosis) project represents a European multicentre study to investigate the influence of genotype on disease phenotypes in sarcoidosis.The baseline phenotype module of GenPhenReSa comprised 2163 Caucasian patients with sarcoidosis who were phenotyped at 31 study centres according to a standardised protocol.From this module, we found that patients with acute onset were mainly female, young and of Scadding type I or II. Female patients showed a significantly higher frequency of eye and skin involvement, and complained more of fatigue. Based on multidimensional correspondence analysis and subsequent cluster analysis, patients could be clearly stratified into five distinct, yet undescribed, subgroups according to predominant organ involvement: 1) abdominal organ involvement, 2) ocular–cardiac–cutaneous–central nervous system disease involvement, 3) musculoskeletal–cutaneous involvement, 4) pulmonary and intrathoracic lymph node involvement, and 5) extrapulmonary involvement.These five new clinical phenotypes will be useful to recruit homogenous cohorts in future biomedical studies.Five new clinical phenotypes of sarcoidosis have been identified by analysing organ manifestations of 1932 patients http://ow.ly/UYLC30jpUkq ER -