TY - JOUR T1 - Outcomes of patients with precapillary pulmonary hypertension admitted to an intensive care unit for acute right heart failure JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/1393003.congress-2017.PA3526 VL - 50 IS - suppl 61 SP - PA3526 AU - Constance Vuillard AU - Xavier Jaïs AU - Caroline Sattler AU - Athénaïs Boucly AU - David Montani AU - Laurent Savale AU - Gerald Simonneau AU - Olivier Sitbon AU - Marc Humbert Y1 - 2017/09/01 UR - http://erj.ersjournals.com/content/50/suppl_61/PA3526.abstract N2 - Introduction: Acute right heart failure (RHF) remains the leading cause of death in patients with precapillary pulmonary hypertension (PH). The impact of extracorporeal life support (ECLS) and urgent transplantation on the outcome of this life threatening condition is unknown.Aims and objectives: to determine the characteristics and survival of patients suffering from pulmonary arterial hypertension (PAH) or chronic thromboembolic PH (CTEPH) admitted to intensive care unit (ICU) for acute RHF in the modern management era.Methods: characteristics and outcomes of 83 patients admitted for acute RHF in an ICU from March 2015 to April 2016 were prospectively analyzed in an observational, single-centre study.Results: Mean age was 59 years. Catecholamines were initiated in 57 (68.5%). Urgent lung transplantation was performed in 10 patients. ECLS was used as a bridge to transplantation in 4 of them. Urgent endarterectomy was performed in 9 patients with CTEPH. Mortality rates in ICU, at 1 month and 3 month were 18, 20 and 28%, respectively. Mortality rates at 3 months in patients <50 years, 50 to 65 years and >65 years and treated with catecholamines was 7, 36 and 52%, respectively. Already known PH (HR 4; p=0.05), catecholamine initiation (HR 5; p=0.03), identification of a triggering factor (HR 2.8; p=0.04), average blood pressure at third day (HR 0.9; p=0.001) and creatinine level (HR 1; p=0,05) were identified as risk factors for mortality at one month.Conclusion: Mortality from acute RHF remains high. However, recent progress in lung graft allocation rules and management of acute RHF dramatically improved outcomes in younger patients. ER -