RT Journal Article
SR Electronic
T1 Curcumin as an Add-on Therapy of Moderate Partially Controlled Asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4695
DO 10.1183/1393003.congress-2017.PA4695
VO 50
IS suppl 61
A1 Edin Jusufovic
A1 Mitja Kosnik
A1 Azra Jusufovic
A1 Munevera Becarevic
A1 Mona Al-Ahmad
A1 Jasmina Nurkic
A1 Munevera Osmic
A1 Alma Nadarevic
A1 Fransi Petrak
A1 Dzenan Halilovic
A1 Rifat Sejdinovic
A1 Besim Prnjavorac
YR 2017
UL http://erj.ersjournals.com/content/50/suppl_61/PA4695.abstract
AB Despite intensive treatment, considerable proportion of patients with asthma remains symptomatic. Anti-inflammatory activity of curcumin has been shown.Aim: analyse the impact of add-on therapy with curcumin in asthma patients on inflammatory parameters, lung function and asthma control.During 2 months, 100 non-smokers (46.8±12.4 years, F/M ratio 1.04) with moderate, partially controlled asthma were treated with moderate dose of inhaled glucocorticoids (IGK) with no changes in dose. Patients were divided into two groups (n=50): curcumin group receiving curcumin 500 mg per os twice daily and control group.Before study, sputum and blood eosinophils (Eo), blood neutrophils, high sensitive C-reactive protein (hsCRP), predicted forced expiratory volume in first second (FEV1%), Asthma Control Test (ACT) and Asthma Quality of Life Questionnaire (AQLQ) were similar between groups.After study, in curcumin group blood Eo count and hsCRP decreased, and FEV1, ACT and AQLQ increased significantly (before vs. after study: Eo: 5.9±0.6 vs. 4.1±0.4; hsCRP: 4.2±0.3 vs. 3.4±0.2; FEV1%: 77.7±0.8 vs. 83.9±0.5; ACT: 14.5 (6,19) vs. 18 (14,21); AQLQ: 3.4±0.2 vs. 4.1±0.2).There was no change in the control group.Compared to control curcumin group showed significantly lower blood Eo and hsCRP and higher FEV1% (curcumin vs. control: Eo: 4.1±0.4 vs. 5.4±0.5; hsCRP: 3.4±0.2 vs. 4.0±0.3; FEV1%: 83.9±0.5 vs. 78.3± 0.8), and improved ACT and AQLQ (ACT change>3: 72% vs. 28%; AQLQ change>0.5: 54% vs. 32%) after study.Add-on therapy with curcumin in patients with moderate partially controlled asthma seems to improve response to IGK regarding lung function, asthma control and quality of life. Further placebo controlled trials are needed.