PT - JOURNAL ARTICLE AU - Nicolas Buchmann AU - Daniel Kohlmann AU - Karin Steinführer AU - Rosina Ledermüller TI - IN-VITRO AEROSOL DEPOSITION OF VALVED HOLDING CHAMBERS FOR CHILDREN WITH BUDESONIDE pMDI AID - 10.1183/1393003.congress-2017.PA3956 DP - 2017 Sep 01 TA - European Respiratory Journal PG - PA3956 VI - 50 IP - suppl 61 4099 - http://erj.ersjournals.com/content/50/suppl_61/PA3956.short 4100 - http://erj.ersjournals.com/content/50/suppl_61/PA3956.full SO - Eur Respir J2017 Sep 01; 50 AB - Efficient pulmonary delivery of aerosol by pMDI in children is particularly difficult due to the child’s breathing frequency, tidal volume and pMDI coordination. Using valved holding chambers (VHC) elevate some of these difficulties. Yet, commercially available VHCs differ greatly in design and material properties, which affect lung deposition. This study compares the new VORTEX® for children (PARI GmbH) to four commercially available VHCs. These are: AeroChamber® Plus Flow-Vu, Trudell; OptiChamber® Diamond, Philips Respironics; L‘espace®, Air Liquid and A2A Spacer®, Clement Clark together with their respective face masks. Tests were conducted in an age-appropriate child face in-vitro model (LIAM, age 3-4y.) with realistic tissue properties. The model was connected to a next generation cascade impactor and the VHCs and Budesonide pMDI (Budiair, Chiesi) were mounted in a fully automated test unit capable of simulating inhalation delay times and age-specific breathing pattern. Tests were carried out according to Ph. Eur. in a 3x3 manner with HPLC analysis and statistics based on ANOVA (95% CI). All VHCs increased (p<0.05) the respirable particle fraction (RPF,<5µm) and the respirable particle dose (RPD,<5µm) and reduced (p<0.05) the oropharyngeal deposition compared to a pMDI alone. Significantly higher delivered dose (DD, p<0.05) and higher respirable dose (p<0.05) was achieved with the new VORTEX® compared to the other tested devices. The tested valveld holding chambers yielded different aerosol performance when compared under standardized condition in a child-specific in-vitro model. This should be considered in daily practice when choosing an appropriate valved holding chamber for children.