RT Journal Article
SR Electronic
T1 Glutathione level in community-acquired pneumonia patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA988
DO 10.1183/1393003.congress-2017.PA988
VO 50
IS suppl 61
A1 Voskresenska, Natalja
A1 Voicehovska, Julija
A1 Babikovs, Sergejs
A1 Voicehovskis, Vladimirs
A1 Lejnieks, Aivars
A1 Skesters, Andrejs
A1 Silova, Alise
YR 2017
UL http://erj.ersjournals.com/content/50/suppl_61/PA988.abstract
AB Glutathione, in its thiol-reduced form (GSH), is the most abundant antioxidant in the airway epithelial lining fluid. It acts as a vital intra- and extracellular antioxidant protecting oxidative/nitrosative stress, interceding the pro-inflammatory processes in the lungs.Aim: Relationship between pneumonia severity and GSH level have been studied.Methods: A case-conrol study took place at P. Stradins Clinical University hospital, Riga, Latvia. Community-acquired pneumonia (CAP) patients with no underlying chronic heart failure (n=32), both males and females of average age 69,0+7,2 and healthy control patients matched for age (n=20) were recruited. CURB 65 (confusion, uremia, respiratory rate, BP, age ≥ 65 years) score was used for CAP severity assessment. The level of plasma GSH was determined. CAP clinical pattern was followed up for 3 weeks.Results: Being compared to control group, GSH level was reduced in CAP patients (mean GSH was 1.12+ 0,22 mmol/L versus 1.60+0,16 mmol/L accordingly). There was no correlation between GSH level and CAP severity by CURB65. However, in 8 patients respiratory failure (RF) has developed. All the patients, in whom RF has developed, demonstrated GSH level below 1,1 mmol/L on admission.Conclusions: A low concentration of plasma GSH indicating low antioxidant capacity could act as a marker for inflammation-related OS in CAP patients for its management and/or risk of complications stratification.