@article {WoehrlePA2283, author = {Holger Woehrle and Jeff Armitstead and Dongquan Liu and Adam Benjafield and Jean-Louis Pepin and Shiyun Shao and Peter Cistulli and Atul Malhotra}, title = {Therapy termination and apnoea-hypopnoea index (AHI)/central apnoea index (CAI) trajectories during continuous positive airway pressure (CPAP) therapy}, volume = {50}, number = {suppl 61}, elocation-id = {PA2283}, year = {2017}, doi = {10.1183/1393003.congress-2017.PA2283}, publisher = {European Respiratory Society}, abstract = {Introduction: There is a lack of data on trajectories of AHI and CAI over time after CPAP initiation, and on the relationship between these trajectory patterns and therapy termination.Aim: This big data analysis investigated time to therapy termination based on AHI and CAI trajectories in patients receiving CPAP for the first time.Methods: We analysed telemonitoring data from the US AirView database for a random sample of 30\% of US patients starting CPAP from 1 Jan to 2 Oct 2015 (inclusion if >=1 session with usage >=1h). The patients were followed up till 31 Dec 2015. Mean follow-up was 166 days (interquartile range 96{\textendash}240). Dropouts were patients who had no usage for 30 consecutive days or changed therapy.Results: 175,326 patients were included; 55,221 (31.5\%) had dropped out by 31 Dec 2015. AHI and CAI values were higher in patients who discontinued CPAP earlier compared with those who continued therapy (see figure; each data point represents a mean of 10-day average AHI or CAI for a patient group at one time point).Conclusion: Although overall residual AHI values were low, small increases in AHI and CAI during the first 180 days on CPAP may be a marker of early termination risk.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/50/suppl_61/PA2283}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }