PT  - JOURNAL ARTICLE
AU  - Kim, Victor
AU  - Zhao, Huaqing
AU  - Armstrong, Hilary
AU  - O'Neal, Wanda
AU  - Bailey, Kristina
AU  - Rennard, Stephen
AU  - Barr, R. Graham
AU  - Criner, Gerard
AU  - Lovasi, Gina
AU  - Morrison, Mary
TI  - Elevated systemic biomarkers and persistent anxiety and depression in smokers with and without COPD: An analysis of the SPIROMICS cohort
AID  - 10.1183/1393003.congress-2017.PA4967
DP  - 2017 Sep 01
TA  - European Respiratory Journal
PG  - PA4967
VI  - 50
IP  - suppl 61
4099  - http://erj.ersjournals.com/content/50/suppl_61/PA4967.short
4100  - http://erj.ersjournals.com/content/50/suppl_61/PA4967.full
SO  - Eur Respir J2017 Sep 01; 50
AB  - Introduction: The systemic biomarkers associated with continued psychiatric symptoms in smokers with and without COPD are not known. We hypothesized that high baseline biomarkers would be associated with anxiety and depression at baseline and a year later.Methods: SPIROMICS is a prospective cohort study that has enrolled 2,981 participants across 4 strata (Never smokers, Smokers without COPD, Mild/Mod COPD, Severe COPD). We examined 1543 smokers with and without COPD and divided them into groups based on the Hospital Anxiety and Depression Scale (HADS), defining Persistent Anxiety (PA+) as HADS-A≥8 at baseline and year 1 (n=222), and Persistent Depression (PD+) as HADS-D≥8 at baseline and year 1 (n=137). We analyzed selected baseline biomarkers, divided them into quartiles and compared the percentages in the upper quartile (referred to as “high”) between groups (PA+ vs. PA- and PD+ vs. PD-) with Chi squared tests.Preliminary Results: The PA+ group had greater percentages of high CBC (30.3 vs. 22.7%, p=0.014), CRP (30.6 vs. 24.1%, p=0.037), and Fibrinogen (31.1 vs. 23.7%, p=0.018). These differences were seen in those ≥60 years old but not <60, and PA+ males had a greater percentage of high CBC, but not females. The PD+ group also had greater percentages of high CBC (34.3 vs. 22.8%, p=0.043), CRP (37.2 vs. 23.8%, p<0.001), and Fibrinogen (32.9 vs. 24.0%, p=0.022). These higher levels of cytokines were seen in females and those <60, but not males or those ≥60.Conclusions: High levels of systemic inflammatory biomarkers are associated with persistent anxiety and depression in smokers with and without COPD, which vary based upon age and gender.