RT Journal Article SR Electronic T1 Validation of smoking status reported by parents and their offspring –The RHINESSA generation study JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA1578 DO 10.1183/1393003.congress-2017.PA1578 VO 50 IS suppl 61 A1 Kathrine Pape A1 Cecilie Svanes A1 Andrei Malinovschi A1 Jõgi A1 Lennart Bråbäck A1 Christer Janson A1 Mathias Holm A1 Jesus Moratalla A1 Jose Louis Maldonado A1 Bryndis Benediktsdottir A1 Caroline Lodge A1 Randi Jacobsen Bertelsen A1 Ane Johannessen A1 Vivi Schlünssen YR 2017 UL http://erj.ersjournals.com/content/50/suppl_61/PA1578.abstract AB Background: Children’s information about their parents’ lifestyle is increasingly used in research, and it is crucial to assess its validity.Aim: To validate offspring’s reports of parents’ smoking status and examine predictors for discrepant answers.Methods: We studied 5678 offspring (18-51yrs) and one of their parents, n=4151 (38-65yrs) participating in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Information about parent’s smoking status during offspring’s childhood was obtained by questionnaires from parents and their offspring. We calculated sensitivity, specificity and Cohens Kappa for agreement (using parent’s own report as the gold standard). We performed logistic regression to examine if offspring gender, age, education, asthma, or own smoking status predicted agreement.Results: The sensitivity for correct offspring report of parents smoking status during childhood (0-10yrs) was 0.83 (95% CI 0.82–0.85), specificity was 0.95 (95% CI 0.94–0.96) and a good agreement was seen (κ = 0.79, 95% CI 0.78–0.81). Similar results were seen for childhood defined as 0-18yrs. Logistic regression analysis showed that fewer discrepant answers were related to younger offspring age (<30yrs = odds ratio [OR] 0.66 (95% CI 0.51–0.86), 30-39yrs OR 0.70 (95% CI 0.54–0.90) reference ≥40yrs) and parents amount of smoking (≥10 cigarettes/day OR 0.56 (95% CI 0.44–0.71) reference <10). Offspring’s gender, education, smoking or asthma status did not predict discrepant answers.Conclusion: Offspring quite correctly report their parents’ smoking status during the offspring’s childhood. In the absence of direct report, offspring’s reports could be valuable.