TY - JOUR T1 - Association of wheeze with lung function decline in children with sickle cell disease JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02433-2016 VL - 50 IS - 5 SP - 1602433 AU - Glenda N. Bendiak AU - Dimas Mateos-Corral AU - Anwar Sallam AU - Eshetu G. Atenafu AU - Melanie Kirby AU - Isaac Odame AU - Peter Bikangaga AU - Padmaja Subbarao AU - Hartmut Grasemann Y1 - 2017/11/01 UR - http://erj.ersjournals.com/content/50/5/1602433.abstract N2 - Emerging evidence suggests that wheezing in children with sickle cell disease (SCD) is associated with higher rates of acute chest syndrome (ACS) and vaso-occlusive crises, independent of a diagnosis of asthma [1, 2]. We investigated the relationships of longitudinal pulmonary function decline with wheeze, asthma and atopy in a cohort of paediatric patients with SCD, using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire [3], skin prick testing (SPT) and airway nitric oxide (NO) measurements.Wheeze in children with sickle cell disease is associated with airflow limitation and lung function decline http://ow.ly/oyZQ30fXnQsWe thank the Brampton SCD Family Group for their help publicising the project, Lani Lieberman for her assistance in designing the protocol, Edwin Ho for assistance in data entry and the Paediatric Consultants at the Hospital for Sick Children for providing funding for the study. ER -