RT Journal Article SR Electronic T1 Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1701162 DO 10.1183/13993003.01162-2017 VO 50 IS 5 A1 Casanova, Ciro A1 Celli, Bartolome R. A1 de-Torres, Juan P. A1 Martínez-Gonzalez, Cristina A1 Cosio, Borja G. A1 Pinto-Plata, Victor A1 de Lucas-Ramos, Pilar A1 Divo, Miguel A1 Fuster, Antonia A1 Peces-Barba, Germán A1 Calle-Rubio, Myriam A1 Solanes, Ingrid A1 Aguero, Ramón A1 Feu-Collado, Nuria A1 Alfageme, Inmaculada A1 De Diego, Alfredo A1 Romero, Amparo A1 Balcells, Eva A1 Llunell, Antonia A1 Galdiz, Juan B. A1 Marin, Margarita A1 Moreno, Amalia A1 Cabrera, Carlos A1 Golpe, Rafael A1 Lacarcel, Celia A1 Soriano, Joan B. A1 López-Campos, José Luis A1 Soler-Cataluña, Juan J. A1 Marin, José M. YR 2017 UL https://publications.ersnet.org//content/50/5/1701162.abstract AB The impact of blood eosinophilia in chronic obstructive pulmonary disease (COPD) remains controversial.To evaluate the prevalence and stability of a high level of blood eosinophils (≥300 cells·μL–1) and its relationship to outcomes, we determined blood eosinophils at baseline and over 2 years in 424 COPD patients (forced expiratory volume in 1 s (FEV1) 60% predicted) and 67 smokers without COPD from the CHAIN cohort, and in 308 COPD patients (FEV1 60% predicted) in the BODE cohort. We related eosinophil levels to exacerbations and survival using Cox hazard analysis.In COPD patients, 15.8% in the CHAIN cohort and 12.3% in the BODE cohort had persistently elevated blood eosinophils at all three visits. A significant proportion (43.8%) of patients had counts that oscillated above and below the cut-off points, while the rest had persistent eosinophil levels <300 cells·μL–1. A similar eosinophil blood pattern was observed in controls. Exacerbation rates did not differ in patients with and without eosinophilia. All-cause mortality was lower in patients with high eosinophils compared with those with values <300 cells·μL–1 (15.8% versus 33.7%; p=0.026).In patients with COPD, blood eosinophils ≥300 cells·μL–1 persisting over 2 years was not a risk factor for COPD exacerbations. High eosinophil count was associated with better survival.The stability of blood eosinophils ≥300 cells per μL is low in COPD patients and it does not confer a poor prognosis http://ow.ly/TwGX30etVIy