TY - JOUR T1 - Why we should improve current practice of diagnosing and treating pulmonary large cell neuroendocrine carcinomas in patients with advanced disease JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01658-2017 VL - 50 IS - 4 SP - 1701658 AU - Jules Derks AU - Robert Jan van Suylen AU - Erik Thunnissen AU - Michael den Bakker AU - Harry Groen AU - Egbert Smit AU - Ronald Damhuis AU - Esther van den Broek AU - Ernst-Jan Speel AU - Anne-Marie C. Dingemans Y1 - 2017/10/01 UR - http://erj.ersjournals.com/content/50/4/1701658.abstract N2 - In response to our manuscript on first-line chemotherapy treatment for metastatic pulmonary large cell neuroendocrine carcinoma (LCNEC) [1], Rossi and co-workers raised their concerns about the validity of our results by questioning the accuracy of LCNEC diagnosis on a biopsy specimen. We would like to thank the authors for their critical appraisal, underscoring the need to increase awareness among pulmonologists, oncologists and pathologists of the diagnostic issues and consequences of metastatic LCNEC diagnosed on a biopsy specimen.Current criteria for LCNEC diagnosed on a biopsy specimen are in need of improvement http://ow.ly/lRP730fu552 ER -