RT Journal Article
SR Electronic
T1 Association between lung cancer somatic mutations and occupational exposure in never-smokers
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1700716
DO 10.1183/13993003.00716-2017
VO 50
IS 4
A1 Paris, Christophe
A1 Do, Pascal
A1 Mastroianni, Bénédicte
A1 Dixmier, Adrien
A1 Dumont, Patrick
A1 Pichon, Eric
A1 Chouaid, Christos
A1 Coudert, Bruno
A1 Foucher, Pascal
A1 Fraboulet, Séverine
A1 Locatelli-Sanchez, Myriam
A1 Baize, Nathalie
A1 Dansin, Eric
A1 Moreau, Lionel
A1 Vincent, Michel
A1 Missy, Pascale
A1 Morin, Franck
A1 Moro-Sibilot, Denis
A1 Couraud, Sébastien
YR 2017
UL http://erj.ersjournals.com/content/50/4/1700716.abstract
AB Occupational exposure constitutes a common risk factor for lung cancer. We observed molecular alterations in 73% of never-smokers, 35% of men and 8% of women were exposed to at least one occupational carcinogen. We report herein associations between molecular patterns and occupational exposure.BioCAST was a cohort study of lung cancer in never-smokers that reported risk factor exposure and molecular patterns. Occupational exposure was assessed via a validated 71-item questionnaire. Patients were categorised into groups that were unexposed and exposed to polycyclic aromatic hydrocarbons (PAH), asbestos, silica, diesel exhaust fumes (DEF), chrome and paints. Test results were recorded for EGFR, KRAS, HER2, BRAF and PIK3 mutations, and ALK alterations.Overall, 313 out of 384 patients included in BioCAST were analysed. Asbestos-exposed patients displayed a significantly lower rate of EGFR mutations (20% versus 44%, p=0.033), and a higher rate of HER2 mutations (18% versus 4%, p=0.084). ALK alterations were not associated with any occupational carcinogens. The DEF-exposed patients were diagnosed with a BRAF mutation in 25% of all cases. Chrome-exposed patients exhibited enhanced HER2 and PIK3 mutation frequency.Given its minimal effects in the subgroups, we conclude that occupational exposure slightly affects the molecular pattern of lung cancers in never-smokers. In particular, asbestos-exposed patients have a lower chance of EGFR mutations.Asbestos exposure is associated with a lower rate of EGFR mutation in lung cancer of never-smokers http://ow.ly/wFUY30fkbcz