TY - JOUR T1 - Endothelial dysfunction and increased platelet reactivity in patients with acute coronary syndrome and undiagnosed COPD: insights into the SCAP trial JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01183-2017 VL - 50 IS - 4 SP - 1701183 AU - Rita Pavasini AU - Francesco Vieceli dalla Sega AU - Francesco Gallo AU - Giulia Passarini AU - Alberto Papi AU - Marco Contoli AU - Gianluca Campo Y1 - 2017/10/01 UR - http://erj.ersjournals.com/content/50/4/1701183.abstract N2 - Unknown/undiagnosed chronic obstructive pulmonary disease (UCOPD) frequently coexists and negatively impacts in the short- and long-term prognosis of patients with coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) [1]. In the Screening for COPD in Acute coronary syndromes Patients (SCAP) trial [2], we recently showed that COPD is frequently undiagnosed in ccute coronary syndrome (ACS) patients with smoking history. Furthermore, we found that a simple screening procedure including peak expiratory flow measurement and respiratory health status questionnaire (RHSQ) might be administered before hospital discharge to discriminate those at risk of UCOPD. In the SCAP study, it was pre-specified that an ancillary analysis aimed to clarify if UCOPD was related to abnormalities in platelet reactivity and endothelial function.Endothelial dysfunction and increased platelet reactivity in acute coronary syndrome with unknown/undiagnosed COPD http://ow.ly/SVEg30eExbKAuthor contributions are as follows. R. Pavasini is the guarantor of the content of the manuscript, including the data and analysis. R. Pavasini, G. Campo, F. Vieceli dalla Sega: conception, design, analysis and interpretation of data. R. Pavasini, G. Campo, M. Contoli, A. Papi: data analysis and interpretation. All authors: drafting of the manuscript and revising it critically for important intellectual content. All authors: final approval of the manuscript submitted. ER -