TY - JOUR T1 - Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00651-2017 VL - 50 IS - 4 SP - 1700651 AU - Anabel L. Castro-Grattoni AU - Gerard Torres AU - Montserrat Martínez-Alonso AU - Ferran Barbé AU - Cecilia Turino AU - Alicia Sánchez-de-la-Torre AU - Anunciacion Cortijo AU - Joaquin Duran-Cantolla AU - Carlos Egea AU - Gonzalo Cao AU - Manuel Sánchez-de-la-Torre Y1 - 2017/10/01 UR - http://erj.ersjournals.com/content/50/4/1700651.abstract N2 - The reduction in blood pressure (BP) with continuous positive airway pressure (CPAP) is modest and highly variable. In this study, we identified the variables that predict BP response to CPAP.24-h ambulatory BP monitoring (ABPM), C-reactive protein (CRP), leptin, adiponectin and 24-h urinary catecholamine were measured before and after 6 months of CPAP in obstructive sleep apnoea (OSA) patients.Overall, 88 middle-aged, obese male patients with severe OSA (median apnoea–hypopnoea index 42 events·h−1) were included; 28.4% had hypertension. 62 patients finished the study, and 60 were analysed. The daytime diastolic BP (−2 mmHg) and norepinephrine (−109.5 nmol·day-1) were reduced after CPAP, but no changes in the 24-h BP, night-time BP, dopamine, epinephrine, CRP, leptin or adiponectin were detected. The nocturnal normotension was associated with an increased night-time-BP (+4 mmHg) after CPAP, whereas nocturnal hypertension was associated with a reduction of 24-h BP (−3 mmHg). A multivariate linear regression model showed differential night-time BP changes after CPAP. Specifically, low night-time heart rate (<68 bpm) and BP dipper profile were associated with increased night-time BP and new diagnosis of nocturnal hypertension.Our results suggest that nocturnal hypertension, circadian BP pattern and night-time heart rate could be clinical predictors of BP response to CPAP and support the usefulness of 24-h ABPM for OSA patients before treatment initiation. These results need to be confirmed in further studies.24-h ambulatory blood pressure monitoring showed predictive value for the blood pressure response to CPAP treatment http://ow.ly/Wuf230dqP4T ER -