RT Journal Article SR Electronic T1 Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1602426 DO 10.1183/13993003.02426-2016 VO 50 IS 2 A1 Rochwerg, Bram A1 Brochard, Laurent A1 Elliott, Mark W. A1 Hess, Dean A1 Hill, Nicholas S. A1 Nava, Stefano A1 Navalesi, Paolo A1 Antonelli, Massimo A1 Brozek, Jan A1 Conti, Giorgio A1 Ferrer, Miquel A1 Guntupalli, Kalpalatha A1 Jaber, Samir A1 Keenan, Sean A1 Mancebo, Jordi A1 Mehta, Sangeeta A1 Raoof, Suhail YR 2017 UL https://publications.ersnet.org//content/50/2/1602426.abstract AB Noninvasive mechanical ventilation (NIV) is widely used in the acute care setting for acute respiratory failure (ARF) across a variety of aetiologies. This document provides European Respiratory Society/American Thoracic Society recommendations for the clinical application of NIV based on the most current literature.The guideline committee was composed of clinicians, methodologists and experts in the field of NIV. The committee developed recommendations based on the GRADE (Grading, Recommendation, Assessment, Development and Evaluation) methodology for each actionable question. The GRADE Evidence to Decision framework in the guideline development tool was used to generate recommendations. A number of topics were addressed using technical summaries without recommendations and these are discussed in the supplementary material.This guideline committee developed recommendations for 11 actionable questions in a PICO (population–intervention–comparison–outcome) format, all addressing the use of NIV for various aetiologies of ARF. The specific conditions where recommendations were made include exacerbation of chronic obstructive pulmonary disease, cardiogenic pulmonary oedema, de novo hypoxaemic respiratory failure, immunocompromised patients, chest trauma, palliation, post-operative care, weaning and post-extubation.This document summarises the current state of knowledge regarding the role of NIV in ARF. Evidence-based recommendations provide guidance to relevant stakeholders.ERS/ATS evidence-based recommendations for the use of noninvasive ventilation in acute respiratory failure http://ow.ly/NrqB30dAYSQ