TY - JOUR T1 - Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00050-2017 VL - 50 IS - 2 SP - 1700050 AU - Myriam Delaunay AU - Jacques Cadranel AU - Amélie Lusque AU - Nicolas Meyer AU - Valérie Gounant AU - Denis Moro-Sibilot AU - Jean-Marie Michot AU - Judith Raimbourg AU - Nicolas Girard AU - Florian Guisier AU - David Planchard AU - Anne-Cécile Metivier AU - Pascale Tomasini AU - Eric Dansin AU - Maurice Pérol AU - Marion Campana AU - Oliver Gautschi AU - Martin Früh AU - Jean-David Fumet AU - Clarisse Audigier-Valette AU - Sébastien Couraud AU - Stéphane Dalle AU - Marie-Thérèse Leccia AU - Marion Jaffro AU - Samia Collot AU - Grégoire Prévot AU - Julie Milia AU - Julien Mazieres Y1 - 2017/08/01 UR - http://erj.ersjournals.com/content/50/2/1700050.abstract N2 - Immunotherapy is becoming a standard of care for many cancers. Immune-checkpoint inhibitors (ICI) can generate immune-related adverse events. Interstitial lung disease (ILD) has been identified as a rare but potentially severe event.Between December 2015 and April 2016, we conducted a retrospective study in centres experienced in ICI use. We report the main features of ICI–ILD with a focus on clinical presentation, radiological patterns and therapeutic strategies.We identified 64 (3.5%) out of 1826 cancer patients with ICI–ILD. Patients mainly received programmed cell death-1 inhibitors. ILD usually occurred in males, and former or current smokers, with a median age of 59 years. We observed 65.6% grade 2/3 severity, 9.4% grade 4 severity and 9.4% fatal ILD. The median (range) time from initiation of immunotherapy to ILD was 2.3 (0.2−27.4) months. Onset tended to occur earlier in lung cancer versus melanoma: median 2.1 and 5.2 months, respectively (p=0.02). Ground-glass opacities (81.3%) were the predominant lesions, followed by consolidations (53.1%). Organising pneumonia (23.4%) and hypersensitivity pneumonitis (15.6%) were the most common patterns. Overall survival at 6 months was 58.1% (95% CI 37.7–73.8%).ICI–ILD often occurs early and displays suggestive radiological features. As there is no clearly identified risk factor, oncologists need to diagnose and adequately treat this adverse event.Awareness of clinical/radiological presentation of immunotherapy-related pneumonitis is crucial to ensure a diagnosis http://ow.ly/eIMF30bgolf ER -