RT Journal Article
SR Electronic
T1 Alcohol consumption as a risk factor for tuberculosis: meta-analyses and burden of disease
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1700216
DO 10.1183/13993003.00216-2017
VO 50
IS 1
A1 Sameer Imtiaz
A1 Kevin D. Shield
A1 Michael Roerecke
A1 Andriy V. Samokhvalov
A1 Knut Lönnroth
A1 Jürgen Rehm
YR 2017
UL http://erj.ersjournals.com/content/50/1/1700216.abstract
AB Meta-analyses of alcohol use, alcohol dosage and alcohol-related problems as risk factors for tuberculosis incidence were undertaken. The global alcohol-attributable tuberculosis burden of disease was also re-estimated.Systematic searches were conducted, reference lists were reviewed and expert consultations were held to identify studies. Cohort and case-control studies were included if there were no temporal violations of exposure and outcome. Risk relations (RRs) were pooled by using categorical and dose-response meta-analyses. The alcohol-attributable tuberculosis burden of disease was estimated by using alcohol-attributable fractions.36 of 1108 studies were included. RRs for alcohol use and alcohol-related problems were 1.35 (95% CI 1.09–1.68; I2: 83%) and 3.33 (95% CI 2.14–5.19; 87%), respectively. Concerning alcohol dosage, tuberculosis risk rose as ethanol intake increased, with evidence of a threshold effect. Alcohol consumption caused 22.02 incident cases (95% CI 19.70–40.77) and 2.35 deaths (95% CI 2.05–4.79) per 100 000 people from tuberculosis in 2014. Alcohol-attributable tuberculosis incidence increased between 2000 and 2014 in most high tuberculosis burden countries, whereas mortality decreased.Alcohol consumption was associated with an increased risk of tuberculosis in all meta-analyses. It was consequently a major contributor to the tuberculosis burden of disease.Alcohol use, alcohol dosage and alcohol-related problems are associated with an increased risk of tuberculosis http://ow.ly/CheO30aPqJg