RT Journal Article
SR Electronic
T1 Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1700051
DO 10.1183/13993003.00051-2017
VO 49
IS 6
A1 Hill, Adam T.
A1 Haworth, Charles S.
A1 Aliberti, Stefano
A1 Barker, Alan
A1 Blasi, Francesco
A1 Boersma, Wim
A1 Chalmers, James D.
A1 De Soyza, Anthony
A1 Dimakou, Katerina
A1 Elborn, J. Stuart
A1 Feldman, Charles
A1 Flume, Patrick
A1 Goeminne, Pieter C.
A1 Loebinger, Michael R.
A1 Menendez, Rosario
A1 Morgan, Lucy
A1 Murris, Marlene
A1 Polverino, Eva
A1 Quittner, Alexandra
A1 Ringshausen, Felix C.
A1 Tino, Gregory
A1 Torres, Antoni
A1 Vendrell, Montserrat
A1 Welte, Tobias
A1 Wilson, Rob
A1 Wong, Conroy
A1 O'Donnell, Anne
A1 Aksamit, Timothy
YR 2017
UL https://publications.ersnet.org//content/49/6/1700051.abstract
AB There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; haemoptysis AND a clinician determines that a change in bronchiectasis treatment is required.The working group proposes the use of this consensus-based definition for bronchiectasis exacerbation in future clinical research involving adults with bronchiectasis.An expert conference has developed a consensus definition of a bronchiectasis exacerbation for clinical research http://ow.ly/oKPY309yTaX